Antifungal Potential of Propolis Extract Against Candida Albicans: Literature Review
Keywords:
Antifungal, MIC, MFC, Propolis, Candida Albicans.
Abstract
The increasing rate of Candida resistance against pharmacological drugs has become a particular focus in the medical world, especially considering the high mortality rate due to systemic infections caused by Candida. It is evident that the urgency of developing alternative medicines applies for potential natural ingredients like propolis. This literature review aims to discuss the antifungal effectiveness of propolis against C. albicans which is described by the MIC (minimum inhibitory concentration) and MFC (minimum fungicidal concentration) values from the test results. The search for relevant literature was conducted using the Google Scholar, ScienceDirect, and PubMed databases using the keywords "Propolis AND MIC AND MFC AND Candida albicans". There were nine articles that had been adjusted to the inclusion and exclusion criteria based on the PICOS Framework. The propolis in the article uses various solvents with various extraction methods, and various antifungal tests are carried out on standardized and clinical isolates of C. albicans. All the reviewed articles consistently support the finding that propolis has a strong ability to inhibit the growth and kill the pathogenic fungus C. albicans. The lowest MIC value found was 0.06 μg/mL, and the MFC value was 0.121 μg/mL. Propolis has potential as an ingredient that can be further developed as a non-pharmacological therapy for pathogenic fungal infections.
References
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2. Agüero, M. B. et al. (2014). Urban propolis from San Juan province (Argentina): Ethnopharmacological uses and antifungal activity against Candida and dermatophytes. Industrial Crops and Products, 57, 166-173.
3. Araújo, M. J. A. M., Bosco, S. de M. G., & Sforcin, J. M. (2016). Pythium insidiosum: inhibitory effects of propolis and geopropolis on hyphal growth. Brazilian Journal of Microbiology, 47(4), 863–869.
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7. Guzelmeric, E. et al. (2018). Authentication of Turkish propolis through HPTLC fingerprints combined with multivariate analysis and palynological data and their comparative antioxidant activity. Lwt - Food Science and Technology, 87, 23–32.
8. Kalista, K. F. et al. (2017). Karakteristik Klinis dan Prevalensi Pasien Kandidiasis Invasif di Rumah Sakit Cipto Mangunkusumo. Jurnal Penyakit Dalam Indonesia, 4(2), 56.
9. Lopes, J. P., & Lionakis, M. S. (2022). Pathogenesis and virulence of Candida albicans. Virulence, 13(1), 89–121.
10. McCarty, T. P., White, C. M., & Pappas, P. G. (2021). Candidemia and Invasive Candidiasis. Infectious disease clinics of North America, 35(2), 389-413.
11. Moghim, H. et al. (2021). Antifungal Effects of Iranian Propolis Extract and Royal jelly Against Candida albicans. International Journal of Preventive Medicine, 12, 163.
12. Mora Carpio, A. L., & Climaco, A. (2023). Fungemia Candidiasis. Treasure Island (FL).
13. Ota, C. et al. (2001). Antifungal activity of propolis on different species of Candida. Mycoses, 44(9–10), 375–378.
14. Page, M. J. et al. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clinical research ed.), 372, 71.
15. Pappas, P. G. et al. (2016). Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 62(4), 1-50.
16. Przybyłek, I., & Karpiński, T. M. (2019). Antibacterial Properties of Propolis. Molecules (Basel, Switzerland), 24(11).
17. R, A. N., & Rafiq, N. B. (2022). Candidiasis, StatPearls Publishing. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK560624/
18. Ramón-Sierra, J. et al. (2019). Partial characterization of ethanolic extract of Melipona beecheii propolis and in vitro evaluation of its antifungal activity. Revista Brasileira de Farmacognosia, 29(3), 319–324. https://doi.org/10.1016/j.bjp.2019.04.002
19. Ristivojević, P. et al. (2018). Profiling of Turkish propolis subtypes: Comparative evaluation of their phytochemical compositions, antioxidant and antimicrobial activities. LWT, 95, 67–379. https://doi.org/10.1016/j.lwt.2018.04.063
20. Robbins, N., Caplan, T., & Cowen, L. E. (2017). Molecular Evolution of Antifungal Drug Resistance. Annual Review of Microbiology, 71(1), 753–775.
21. Robbins, N., Wright, G. D., & Cowen, L. E. (2016). Antifungal Drugs: The Current Armamentarium and Development of New Agents. Microbiology Spectrum, 4(5).
22. Sanchez Armengol, E., Harmanci, M., & Laffleur, F. (2021). Current strategies to determine antifungal and antimicrobial activity of natural compounds. Microbiological Research, 252, 126867. https://doi.org/10.1016/j.micres.2021.126867
23. Shehu, A. et al. (2016). Antifungal Properties of Malaysian Tualang Honey and Stingless Bee Propolis against Candida Albicans and Cryptococcus Neoformans. Journal of Applied Pharmaceutical Science, 6, 44–50.
24. Sokolonski, A. R. et al. (2021). Activity of antifungal drugs and Brazilian red and green propolis extracted with different methodologies against oral isolates of Candida spp. BMC complementary medicine and therapies, 21(1), 286.
25. Szabó, K. et al. (2021). The phosphatome of opportunistic pathogen Candida species. Fungal Biology Reviews, 35, 40–51. https://doi.org/10.1016/j.fbr.2020.12.002
26. Zabaiou, N. et al. (2017). Biological properties of propolis extracts: Something new from an ancient product. Chemistry and physics of lipids, 207(Pt B), 214-222.
27. Zulhendri, F. et al. (2021). Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review. Foods (Basel, Switzerland), 10(6).
2. Agüero, M. B. et al. (2014). Urban propolis from San Juan province (Argentina): Ethnopharmacological uses and antifungal activity against Candida and dermatophytes. Industrial Crops and Products, 57, 166-173.
3. Araújo, M. J. A. M., Bosco, S. de M. G., & Sforcin, J. M. (2016). Pythium insidiosum: inhibitory effects of propolis and geopropolis on hyphal growth. Brazilian Journal of Microbiology, 47(4), 863–869.
4. Barros, I. L. E. et al. (2022). Promising effect of propolis and a by-product on planktonic cells and biofilm formation by the main agents of human fungal infections. Anais da Academia Brasileira de Ciencias, 94(2), e20210189.
5. CDC. (2022). Candidiasis. Retrieved from: https://www.cdc.gov/fungal/diseases/candidiasis/index.html
6. Gavanji, S., & Larki, B. (2017). Comparative effect of propolis of honey bee and some herbal extracts on Candida albicans. Chinese Journal of Integrative Medicine, 23(3), 201–207.
7. Guzelmeric, E. et al. (2018). Authentication of Turkish propolis through HPTLC fingerprints combined with multivariate analysis and palynological data and their comparative antioxidant activity. Lwt - Food Science and Technology, 87, 23–32.
8. Kalista, K. F. et al. (2017). Karakteristik Klinis dan Prevalensi Pasien Kandidiasis Invasif di Rumah Sakit Cipto Mangunkusumo. Jurnal Penyakit Dalam Indonesia, 4(2), 56.
9. Lopes, J. P., & Lionakis, M. S. (2022). Pathogenesis and virulence of Candida albicans. Virulence, 13(1), 89–121.
10. McCarty, T. P., White, C. M., & Pappas, P. G. (2021). Candidemia and Invasive Candidiasis. Infectious disease clinics of North America, 35(2), 389-413.
11. Moghim, H. et al. (2021). Antifungal Effects of Iranian Propolis Extract and Royal jelly Against Candida albicans. International Journal of Preventive Medicine, 12, 163.
12. Mora Carpio, A. L., & Climaco, A. (2023). Fungemia Candidiasis. Treasure Island (FL).
13. Ota, C. et al. (2001). Antifungal activity of propolis on different species of Candida. Mycoses, 44(9–10), 375–378.
14. Page, M. J. et al. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clinical research ed.), 372, 71.
15. Pappas, P. G. et al. (2016). Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 62(4), 1-50.
16. Przybyłek, I., & Karpiński, T. M. (2019). Antibacterial Properties of Propolis. Molecules (Basel, Switzerland), 24(11).
17. R, A. N., & Rafiq, N. B. (2022). Candidiasis, StatPearls Publishing. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK560624/
18. Ramón-Sierra, J. et al. (2019). Partial characterization of ethanolic extract of Melipona beecheii propolis and in vitro evaluation of its antifungal activity. Revista Brasileira de Farmacognosia, 29(3), 319–324. https://doi.org/10.1016/j.bjp.2019.04.002
19. Ristivojević, P. et al. (2018). Profiling of Turkish propolis subtypes: Comparative evaluation of their phytochemical compositions, antioxidant and antimicrobial activities. LWT, 95, 67–379. https://doi.org/10.1016/j.lwt.2018.04.063
20. Robbins, N., Caplan, T., & Cowen, L. E. (2017). Molecular Evolution of Antifungal Drug Resistance. Annual Review of Microbiology, 71(1), 753–775.
21. Robbins, N., Wright, G. D., & Cowen, L. E. (2016). Antifungal Drugs: The Current Armamentarium and Development of New Agents. Microbiology Spectrum, 4(5).
22. Sanchez Armengol, E., Harmanci, M., & Laffleur, F. (2021). Current strategies to determine antifungal and antimicrobial activity of natural compounds. Microbiological Research, 252, 126867. https://doi.org/10.1016/j.micres.2021.126867
23. Shehu, A. et al. (2016). Antifungal Properties of Malaysian Tualang Honey and Stingless Bee Propolis against Candida Albicans and Cryptococcus Neoformans. Journal of Applied Pharmaceutical Science, 6, 44–50.
24. Sokolonski, A. R. et al. (2021). Activity of antifungal drugs and Brazilian red and green propolis extracted with different methodologies against oral isolates of Candida spp. BMC complementary medicine and therapies, 21(1), 286.
25. Szabó, K. et al. (2021). The phosphatome of opportunistic pathogen Candida species. Fungal Biology Reviews, 35, 40–51. https://doi.org/10.1016/j.fbr.2020.12.002
26. Zabaiou, N. et al. (2017). Biological properties of propolis extracts: Something new from an ancient product. Chemistry and physics of lipids, 207(Pt B), 214-222.
27. Zulhendri, F. et al. (2021). Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review. Foods (Basel, Switzerland), 10(6).
Published
2023-12-06
How to Cite
Soerjanto, O. M., Endraswari, P. D., & Purba, A. K. R. (2023). Antifungal Potential of Propolis Extract Against Candida Albicans: Literature Review. International Journal of Science and Society, 5(5), 955-966. https://doi.org/10.54783/ijsoc.v5i5.963
Section
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