Effectiveness of Sonification of Ketumbar Tip (Coriandrum Sativum L.) for Diabetes Melites Complications on the Gynels with Manly Wistar Rats (Rattus Norvegicus) as Aloksan Induced Coal Animals

Irza Haicha  Pratama; Angelika Sio  Siagian; Faskanita Maristella  Nadapdap; Syahdina Saufa Yardha  Chaniago; Laura Novi  Silalahi

doi:10.54783/ijsoc.v5i5.958

Irza Haicha Pratama Universitas Prima Indonesia, Medan, Indonesia
Angelika Sio Siagian Universitas Prima Indonesia, Medan, Indonesia
Faskanita Maristella Nadapdap Universitas Prima Indonesia, Medan, Indonesia
Syahdina Saufa Yardha Chaniago Universitas Prima Indonesia, Medan, Indonesia
Laura Novi Silalahi Universitas Prima Indonesia, Medan, Indonesia

DOI: https://doi.org/10.54783/ijsoc.v5i5.958

Keywords: Sonification, coriander seeds, GFR, uACR.

Abstract

The most common microvascular complication is diabetic nephropathy. Coriander is traditionally used as a stimulant, carminative, anticonvulsant, diuretic and antirheumatic, antiemetic and has potential as an antioxidant. Thus, the authors were interested in exploring the effectiveness of coriander seed sonification (Coriandrum sativum L.) on complications of diabetes mellitus in alloxan-induced male rats as experimental animals, especially on kidney micro-vascularization. This study was an experimental study. In this study, sonification of coriander seeds was carried out using a sonicator. All rats in this study were induced by injection of 5% alloxan, then grouped into 5 different groups including: control (Na-CMC), standard (metformin), coriander seed sonification 200 mg/kgBW, 400 mg/kgBW, and 800 mg/kgBW. The measured parameters in this study were GFR and uACR. The results revealed that the coriander seed sonification in this study significantly increased the GFR value and reduced uACR in line with the increase in the administered dose of coriander sonification (p value < 0.05). Hence, it can be concluded that coriander seed sonification has a protective effect against kidney damage due to diabetes.

References

Aftab, A., Haider, M., Ali, Q., & Malik, A. (2021). Genetic Evaluation for Morphological Traits of Coriandrum Sativum Grown Under Salt Stress. Biological and Clinical Sciences Research Journal, 2(1), 1–7. https://doi.org/10.54112/bcsrj.v2021i1.52

Anggraini, D., Sutyarso, S., Kanedi, M., & Busman, H. (2019). Pengaruh Pemberian Ekstrak Etanol Jahe Merah (Zingiber Officinale Roxb var Rubrum) Terhadap Kuantitas dan Kualitas Spermatozoa Mencit Jantan (Mus musculus L.) Yang Diinduksi Paraquat Diklorida. Jurnal Ilmiah Biologi Eksperimen Dan Keanekaragaman Hayati, 5(2), 47–54. https://doi.org/10.23960/jbekh.v5i2.53

Besseling, P. J. et al. (2021). A plasma creatinine and urea-based equation to estimate glomerular filtration rate in rats. American Journal of Physiology-Renal Physiology, 320(3), 518–524.

Bulqis, A. R., Manik Ermayanti, N. G. A., & Wirasiti, N. (2020). Perbedaan Kualitas Sperma Pada Pasien Penderita Diabetes Mellitus Tipe 1 Dan 2 di RSUD. Lamadukelleng, Sengkang, Sulawesi Selatan. Simbiosis, 8(1), 17. https://doi.org/10.24843/jsimbiosis.2020.v08.i01.p03

Chiang, J. L., Kirkman, M. S., Laffel, L. M. B., & Peters, A. L. (2014). Type 1 diabetes through the life span: A position statement of the American Diabetes Association. Diabetes Care, 37(7), 2034–2054. https://doi.org/10.2337/dc14-1140

Chiuman, L. et al. (2021). Improvement of Liver Function from Lemon Pepper Fruit Ethanol Extract in Streptozotocin-Induced Wistar Rats,” in 2021 IEEE International Conference on Health, Instrumentation & Measurement, and Natural Sciences (InHeNce). Medan, Indonesia: IEEE.

Cho, N. H., Shaw, J. E., Karuranga, S., Huang, Y., da Rocha Fernandes, J. D., Ohlrogge, A. W., & Malanda, B. (2018). IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Research and Clinical Practice, 138, 271–281. https://doi.org/10.1016/j.diabres.2018.02.023

Dennedy, M. C., Rizza, R. A., & Dinneen, S. F. (2015). Classification and Diagnosis of Diabetes Mellitus. Endocrinology: Adult and Pediatric, 1–2(January), 662-671.e2. https://doi.org/10.1016/B978-0-323-18907-1.00038-X

Dersing, K., Rusmini, H. and Triwahyuni, T. (2020). Efektivitas Ekstrak Ketumbar (Coriandrum sativum L.) terhadap Penurunan Kadar Gula Darah Tikus Putih Jantan (Rattus norvegicus L.) Galur Wistar yang Diinduksi Aloksan. Jurnal Kedokteran Raflesia, 6(1), 36-44.

Dersing, K., Rusmini, H., & Triwahyuni, T. (2020). Efektivitas Ekstrak Ketumbar (Coriandrum sativum L.) Terhadap Penurunan Kadar Gula Darah Tikus Putih Jantan (Rattus norvegicus L.) Galur Wistar yang Diinduksi Aloksan. Journal Kedokteran Raflesia, 6(1), 36–44.

Dewanto, H. N., Lisdiana, & Isnaeni, W. (2017). Pengaruh Ekstrak Kulit Buah Rambutan terhadap Kualitas Sperma Tikus yang Terpapar Asap Rokok. Life Science, 6(2), 62–68.

Dwi, P., Sri, M., & Choirul, A. (2018). Pengaruh Berbagai Konsentrasi Air Rebusan Ketumbar (Coriandrum Sativum) terhadap Penurunan Angka Kuman Tiang Infus di Puskesmas Rawat Inap Sewon I Bantul. Sanitasi Jurnal Kesehatan Lingkungan, 10(2), 90–95. https://doi.org/10.29238/sanitasi.v10i1.182

Fatimah, P. S., & Siregar, P. A. (2019). Pola Konsumsi Buah Dan Sayur Dengan Kejadian Diabetes Mellitus Pada Masyarakat Pesisir. Bali Health Published Journal, 2(1), 26–36.

Firman, R. C., & Simmons, L. W. (2010). Sperm midpiece length predicts sperm swimming velocity in house mice. Biology Letters, 6(4), 513–516. https://doi.org/10.1098/rsbl.2009.1027

Fitriani, N., & Erlyn, P. (2019). Aktivitas Antidiabetik Kombinasi Ekstrak Etanol Daun Ciplukan (Physalis angulata) dan Daun Gaharu (Aquilaria malaccensis) pada Tikus Diabetes. Syifa’ MEDIKA: Jurnal Kedokteran dan Kesehatan, 9(2), 70. https://doi.org/10.32502/sm.v9i2.1660

Guyton, A. C., & Hall, J. E. (2014). Buku Ajar Fisiologi Kedokteran. EGC.

Hamel, D. V, Sambou, C., Karauwan, F. A., & Ginting, M. (2021). Uji Efektivitas Infusa Biji Ketumbar Coriandrum sativum L. Sebagai Antikolesterol Pada Tikus Putih Rattus norvegicus. Jurnal Biofarmasetikal Tropis, 4(1), 45–52.

Haryoto, H., & Nur’aini, A. R. (2018). Antidiabetes Melitus Ekstrak Etanol Batang dan Daun Ubi Jalar Kuning (Ipomoea batatas Linn.) Terhadap Kadar Glukosa Pada Tikus Jantan. Jurnal Farmasi Sains dan Praktis, 4(2), 1–8. https://doi.org/10.31603/pharmacy.v4i2.2313

Hasanah, N., & Dori, R. S. (2019). Daya Hambat Ekstrak Biji Ketumbar (Coriandrum Sativum L) Terhadap Pertumbuhan Bakteri Shigella Dysenteriae Metode Cakram. Edu Masda Journal, 3(2), 115. https://doi.org/10.52118/edumasda.v3i2.33

Hasnita, AZ, R., & Astuti, A. (2019). Hubungan Durasi Penyakit dan Kadar Gula Darah Dengan Keluhan Subyektif Pada Penderita Diabetes Mellitus Tipe II di Puskesmas Putri Ayu Kota Jambi.

Hikmah, N., & Khaerati, K. (2016). Pengaruh Pemberian Ekstrak Daun Salam (Syzygium polyanthum Wight.) Terhadap Glibenklamid dalam Menurunkan Kadar Glukosa Darah Mencit (Mus musculus) yang Diinduksi Aloksan. Journal of Pharmacy, 2(1), 24–30.

Jangra, S. S., Madan, V. K., & Singh, I. (2017). Coriander (Coriandrum sativum L.) - An important medicinal plant for antioxidant activity: A review. Open Access Journal of Medicinal and Aromatic Plants, 8(2), 9–25.

Josten, S., Mutmainnah, & Hardjoeno. (2006). Profil Lipid Penderita Diabetes Mellitus Tipe 2. Indonesian Journal, 13(1), 20–22.

Kajal, A., & Singh, R. (2019). Coriandrum sativum seeds extract mitigate progression of diabetic nephropathy in experimental rats via AGEs inhibition. PLoS One, 14(3), 1-13.

Kemenkes, R. P. (2020). InfoDATIN Tetap Produktif, Cegah, dan Atasi Diabetes Melitus.

Kumar, D., & Chauhan, P. (2018). Coriandrum Sativum: A Multipurpose Medicinal Plant-A Review. World Journal of Pharmaceutical Research, 7(15), 322–327.

Laia, J. (2020). Hubungan Tingkat Kepatuhan Diet Makan Dengan Tingkat Kadar Gula Darah Pasien Diabetes Melitus. Jurnal Ilmiah Wijaya, 12, 92–97.

Maleki, S. J., Crespo, J. F., & Cabanillas, B. (2019). Anti-inflammatory effects of flavonoids. Food Chemistry, 299, 125124. https://doi.org/10.1016/j.foodchem.2019.125124

Melita, D., Dasrul, D., & Adam, M. (2014). The Effect of Bull Age and Ejaculation Frequency on Quality of Aceh Bull Spermatozoa. Jurnal Medika Veterinaria, 8(1), 15–19. https://doi.org/10.21157/j.med.vet..v8i1.3323

Meliyana, Y., & Nugroho, R. A. (2016). Pengaruh Rebusan Daun Binahong (Anredera cordifolia) Terhadap Kualitas Spermatozoa Mencit (Mus musculus L.) Diabetes. Bioprospek, 11(2), 32–41.

Muntafiah, A., Pratama, T. S., & Ati, V. R. B. (2019). Evaluasi Potensi Antidiabetes Sari Buah Markisa Ungu (Passiflora edulis var edulis) pada Tikus Model Diabetes Melitus yang Diinduksi Aloksan. Jurnal Kedokteran Brawijaya, 30(3), 191. https://doi.org/10.21776/ub.jkb.2019.030.03.5

Muthmainnah. (2017). Skrinning Fitokimia Senyawa Metabolit Sekunder Dari Ekstrak Etanol Buah Delima (Punica granatum L.) Dengan Metode Uji Warna. Medis Farmasi Poltekkes Makassar, 13.

Nangoy, B. N., De Queljoe, E., & Yudistira, A. (2019). Uji Aktivitas Antidiabetes Dari Ekstrak Daun Sesewanua (Clerodendron squamatum Vahl.) Terhadap Tikus Putih Jantan Galur Wistar (Rattus norvegicus L.). Pharmacon, 8(4), 774. https://doi.org/10.35799/pha.8.2019.29353

Naquvi, K. J. et al. (2011). Review on Role of Natural Αlpha-Glucosidase Inhibitors for Management of Diabetes Mellitus. International Journal of Biomedical Research, 2(6), 374–380.

Nasution, F., Andilala, & Siregar, A. A. (2021). Faktor Risiko Kejadian Diabetes Mellitus. Jurnal Ilmu Kesehatan, 9(2), 94–102.

Nazira, S., Thadeus, M. S., & Hardini, N. (2020). Uji Efektivitas Ekstrak Biji Ketumbar (Coriandrum Sativum L.) Terhadap Gambaran Histopatologi Ginjal Tikus Hiperkolesterolemia Diabetes. Jurnal Muara Sains, Teknologi, Kedokteran Dan Ilmu Kesehatan, 4(2), 357. https://doi.org/10.24912/jmstkik.v4i2.8249

Nugroho, S. (2015). Pencegahan Dan Pengendalian Diabetes Melitus Melalui Olahraga. Medikora, IX(1). https://doi.org/10.21831/medikora.v0i1.4640

Omolaoye Temidayo, S., & Du Plessis Stefan, S. (2018). Diabetes mellitus and male infertility. Asian Pacific Journal of Reproduction, 7(1), 6–14. https://doi.org/10.4103/2305-0500.220978

Parmar, R. R., Jain, K. R., & Modi, C. K. (2011, April). Image morphological operation based quality analysis of coriander seed (Coriandrum satavum L). In 2011 International Conference on Emerging Trends in Networks and Computer Communications (ETNCC) (pp. 482-486). IEEE. https://doi.org/10.1109/etncc.2011.6255886

Patschan, D., & Müller, G. A. (2016). Acute Kidney Injury in Diabetes Mellitus. International Journal of Nephrology, 2016.

Permata, E., Munarto, R., & Orlando, G. (2016). Identifikasi Sperma Sapi Normal Dan Abnormal Menggunakan Algoritma Jaringan Saraf Tiruan. Simetris: Jurnal Teknik Mesin, Elektro dan Ilmu Komputer, 7(1), 135. https://doi.org/10.24176/simet.v7i1.497

Prastika, D. A., & Sugita. (2018). Efektivitas Rendaman Biji Ketumbar (CORIANDRUM SATIVUM L) Untuk Terapi Masalah Keputihan Pada Wanita Usia Subur. Jurnal Terpadu Ilmu Kesehatan, 7.

Prastika, Z., Susilowati, S., Agustono, B., Safitri, E., Fikri, F., & Prastiya, R. A. (2018). Motilitas dan Viabilitas Spermatozoa Sapi Rambon di Desa Kemiren Banyuwangi. Jurnal Medik Veteriner, 1(2), 38. https://doi.org/10.20473/jmv.vol1.iss2.2018.38-42

Price, S. A., & Wilson, L. M. (2005). Pathophysiology: Clinical Concepts of Disease Processes. EGC.

Pulungan, A. B., Annisa, D., & Imada, S. (2019). Diabetes Melitus Tipe-1 pada Anak: Situasi di Indonesia dan Tata Laksana (Type 1 diabetes mellitus in children: situation and management in Indonesia). Sari Pediatri, 20(6), 392.

Rizki, A. U., Cholid, C., & Amalia, M. (2017). Perbedaan Efektivitas Ekstrak Rimpang Temulawak (Curcuma xanthorriza Roxb.) Dengan Ekstrak Daun Salam (Eugenia polyantha Wight) Pada Penurunan Kadar Kolesterol Total Tikus Putih Jantan (Rattus norvegicus). Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan, 10(1). https://doi.org/10.33533/jpm.v10i1.14

Rosmiati, K., & Aritonang, B. N. R. S. (2020). Kajian Fitokimia Dan Aktifitas Antihiperkolesterolemia Ekstrak Ketumbar (Coriandrum sativum L) Pada Mencit Swiss Webster. Media Farmasi, 16(2), 193. https://doi.org/10.32382/mf.v16i2.1755

Sadick, M. et al. (2011). Two non-invasive GFR-estimation methods in rat models of polycystic kidney disease: 3.0 Tesla dynamic contrast-enhanced MRI and optical imaging. European Renal Association, 26(10), 3101–3108.

Saputra, N. T., Suartha, I. N., & Dharmayudha, A. A. G. O. (2018). Agen Diabetagonik Streptozotocin untuk Membuat Tikus Putih Jantan Diabetes Mellitus. Buletin Veteriner Udayana, 10(2), 116. https://doi.org/10.24843/bulvet.2018.v10.i02.p02

Sari, M., Ginting, C. N. and Yulizal, O. (2021). Sunkist peel ethanol extract ameliorates diabetic nephropathy in streptozotocin-induced diabetic wistar rats. Open Access Macedonian Journal of Medical Sciences, 9(A), 1086–1091.

Saxena, S. N., & Agarwal, D. (2019). Pharmacognosy and phytochemistry of coriander (Coriandrum sativum L.). International Journal of Seed Spices, 9(1), 1–13.

Sherwood, L. (2014). Fisiologi Manusia: Dari Sel ke Sistem. EGC.

Sinaga, D. (2021). Pengaruh Ekstrak Dan Fraksi Metanol Buah Kurma (Phoenix Dactylifera) Ajwa Terhadap Histologi Testis, Jumlah Sperma, Dan Viabilitas Spermatozoa Pada Tikus Putih (Rattus norvegicus) Jantan Galur Spraque Dawley. Majalah Kedokteran Andalas, 44(1), 28-40.

Sudatri, N. W., Yulihastiti, D. A., & Suartini, N. M. (2019). Penurunan kualitas sperma tikus (Rattus norvegicus) yang diinjeksi vitamin C dosis tinggi dalam jangka waktu lama. The of Biological Sciences, 6(1), 7–13.

Susanti, N. M. P., Budiman, I. N., & Warditiani, N. K. (2015). Skrining Fitokimia Ektrak Etanol 90% Daun Katuk (Sauropus androgynus (L.) Merr.). Repository Universitas Udayana, 83–86.

Susilawati, T. (2011). Spermatology. Malang: Universitas Brawijaya Press.

Triatmoko, B., Almuttaqin, H., & Dianasari, D. (2018). Uji Aktivitas Antibakteri Kombinasi Minyak Atsiri Biji Ketumbar (Coriandrum sativum L.) dan Gentamisin terhadap Staphylococcus epidermidis (Antibacterial Activity Test Combination of Coriander Seeds Essential Oil (Coriandrum sativum L) and Gentamicin. E-Jurnal Pustaka Kesehatan, 6(3), 421–425.

Yulianty, O., & Nugroho, R. A. (2015). Prosiding Seminar Tugas Akhir FMIPA UNMUL.

Zhang, L. J., Zhou, W. J., Ni, L., Huang, M. Q., Zhang, X. Q., & Xu, H. Y. (2021). A review on chemical constituents and pharmacological activities of Ormosia. Chinese Traditional and Herbal Drugs, 52(14), 4433–4442. https://doi.org/10.7501/j.issn.0253-2670.2021.14.035.