The Effect of Alternative Therapy for Moringa Leaf and Date Palm Juice on Gout

Aris  Fitriyani; Maisje Marlyn  Kuhu; Esti Dwi  Widayanti; Em Sutrisna

doi:10.54783/ijsoc.v5i5.921

Aris Fitriyani Poltekkes Ministry of Health Semarang, Indonesia
Maisje Marlyn Kuhu Poltekkes Ministry of Health Semarang, Indonesia
Esti Dwi Widayanti Poltekkes Ministry of Health Semarang, Indonesia
Em Sutrisna Muhammadiyah University of Surakarta, Indonesia

DOI: https://doi.org/10.54783/ijsoc.v5i5.921

Keywords: Moringa Leaf and Date Juice; Decreased Uric Acid Levels.

Abstract

Gout is becoming increasingly prevalent among younger individuals and is impacting work productivity due to the pain associated with the condition, both globally and in Indonesia. Treatment for gout includes both medical and non-medical approaches. Non-medical alternatives, such as utilizing Moringa leaves and dates, are relatively unknown among the Indonesian population. Therefore, there is a need for alternative therapies involving Moringa leaves. This study aimed to assess the variation in uric acid levels before and after administering alternative therapy using Moringa leaf and date palm juice in Banyumas Regency. The method used was a quasi-experiment without a control group. The research population was all people from adult age in the Banyumas Regency area, totaling 480 people. The sample selection technique was carried out using random sampling with a sample size of 107 respondents as the intervention group. The research instrument is a questionnaire. Data analysis uses the T-Test. The results of giving moringa and date juice were effective in reducing respondents' uric acid levels with p = 0.000 after giving the juice for 10 days which was drunk at night as much as 180 ml consisting of moringa leaves, dates and honey.

References

Abdulkadir, W., Papeo, D. R. P., Akuba, J., & Makkulaw, A. (2022). Antihyperuricemia effect of ethanol extract of pandan leaves (pandanus amaryllifolius) on mice (mus musculus). Journal of Syifa Sciences and Clinical Research. 4(2), 540-547. https://doi.org/10.37311/jsscr.v4i2.7719540

Aminah, E., Saputri, M. E., & Wowor, T. J. F. (2022). The effectiveness of warm compresses in reducing pain in gouty arthritis sufferers in the working area of Pulosari Community Health Center, Pandeglang Banten Regency in 2021. Journal of Nursing, 10(1), 1. https://doi.org/10.35790/jkp.v10i1.37704

Arumsasi, R. (2019). Nursing care for the elderly with nursing problems at risk of falling at the Tresna Werdha Magetan social institution. Retrieved from: http://eprints.umpo.ac.id/5370/

Arjani, I. (2018). Description of uric acid levels, blood glucose and level of knowledge of elderly people in Samsam village, Kerambitan sub-district, Tabanan regency. Meditory: The Journal of Medical Laboratory, 6(1), 46–55. https://doi.org/10.33992/m.v6i1.229

Asrori, A., Nurhayati, N., Mutholib, A., & Ellinasari, T. F. (2020). Description of uric acid levels in welding workshop workers in Sukarami subdistrict, Palembang in 2019. Journal of Health Analysis, 8(2), 63-71.

Bruno, C. M., Pricoco, G., Cantone, D., Marino, E., & Bruno, F. (2016). Tubular handling of uric acid and factors influencing its renal excretion: a short review. EMJ Nephrol, 92-97.

Burns. C. M., & Wortmann, R. L. (2015). Disorders of purine & pyrimidine metabolism. McGraw-Hill.

Choi, H. K., Gao, X., & Curhan, G. (2009). Vitamin C intake and the risk of gout in men: a prospective study. Archives of internal medicine, 169(5), 502-507.

Eso, A., Hamra, M. Y., & Ahmadi, A. P. (2014). Relationship between Hyperuricemia, Obesity, and History of Smoking with the Incident of Hypertension. Medulla, 1(2), 41-47.

Dayana, B., & Bahrudin, U. (2015). Hubungan antara intensitas aktivitas fisik dan kadar asam urat serum pada populasi sindrom metabolik. Jurnal Kedokteran Diponegoro, 4(4), 509-521.

Fadlilah, S., & Sucipto, A. (2018). Analisis Faktor Yang Berhubungan Dengan Kadar Asam Urat Pada Masyarakat Dusun Demangan Wedomartani, Ngemplak, Sleman, Yogyakarta. Jurnal Keperawatan Respati Yogyakarta, 5(1), 295-301.

Gao, X., Curhan, G., Forman, J. P., Ascherio, A., & Choi, H. K. (2008). Vitamin C intake and serum uric acid concentration in men. The Journal of rheumatology, 35(9), 1853-1858.

Ginting, P. C. B. (2020). Gambaran Pengetahuan Lansia Berdasarkan Karakteristik Tentang Penyakit Asam Urat di Puskesmas Pancur Batu Kabupaten Deli Serdang Tahun 2019.

Haidari, F., Rashidi, M. R., Eshraghian, M. R., Mahboob, S. A., Shahi, M. M., & Keshavarz, S. A. (2008). Hypouricemic and antioxidant activities of Allium cepa Lilliaceae and quercetin in normal and hyperuricemic rats. Saudi medical journal, 29(11), 1573-1579.

Halaby, M. S., Metwally, E. M., & Omar, A. A. (2013). Effect of Moringa oleifera on serum lipids and kidney function of hyperlipidemic rats. J. Appl. Sci. Res, 9(5), 189-198.

Harlina, R. P. (2020). Gambaran Kadar Asam Urat Pada Lansia (Studi Di Puskesmas Maospati, Kabupaten Magetan) (Doctoral dissertation, STIKes Insan Cendekia Medika Jombang).

Hertog, M. G., Hollman, P. C., & Katan, M. B. (1992). Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. Journal of agricultural and food chemistry, 40(12), 2379-2383.

Horowitz, J. F., & Klein, S. (2000). Lipid metabolism during endurance exercise. The American journal of clinical nutrition, 72(2), 558S-563S.

Ilyas, N. O., Suprihartono, F. A., & Dewi, M. (2014). Beberapa Faktor yang Berhubungan dengan Kejadian Hiperurisemia pada Pasien Rawat Jalan di RS Dustira Cimahi. Gizi Indonesia, 37(2), 91-100.

Jaliana, Suhadi, & Sety, L. O. M. (2018). Faktor-Faktor yang Berhubungan dengan Kejadian Asam Urat pada Usia 20-44 Tahun di RSUD Bahteramas Provinsi Sulawesi Tenggara Tahun 2017. Jurnal Ilmiah Mahasiawa Kesehatan Masyarakat, 3(2), 30-50.

Jaliana, J., & Suhadi, S. (2018). Factors associated with the incidence of gout in those aged 20-44 years at Bahteramas Regional Hospital, Southeast Sulawesi Province in 2017. Public Health Student Scientific Journal, 3(2).

Junadi. (2012). Rheumatism and Gout. Jakarta: Bhuana Popular Science.

Karuniawati, B. (2018). Hubungan Usia Dengan Kadar Asam Urat Pada Wanita Dewasa. Jurnal Kesehatan Stikes Madani, 9(2), 19-22.

Kasolo, J. N., Bimenya, G. S., Ojok, L., Ochieng, J., & Ogwal-Okeng, J. W. (2010). Phytochemicals and uses of Moringa oleifera leaves in Ugandan rural communities. Journal of Medicinal Plants Research, 4(9), 753-757.

Kinase, J. (2014). Moringa tea blocks acute lung inflammation induced by swine confinement dust through a mechanism involving TNF-α expression, c-Jun N-terminal kinase activation and neutrophil regulation. American Journal of Immunology, 10(2), 73-87.

Kristinawati & Nurlaela. (2013). The effect of administering moringa fruit filtrate (moringa oliefera) on uric acid levels in Wistar strain white rats (rattus norvegicus) experimental animals. Scientific Development Media, 7(6), 27-32.

Luqman, S., Srivastava, S., Kumar, R., Maurya, A. K., & Chanda, D. (2012). Experimental assessment of Moringa oleifera leaf and fruit for its antistress, antioxidant, and scavenging potential using in vitro and in vivo assays. Evidence-Based Complementary and Alternative Medicine, 2012.

Meisenberg, G., & Simmons, W. H. (2011). Principles of Medical Biochemistry E-Book. Philadelphia: Elsevier Health Sciences.

Mohan, M., Gulecha, V. S., Aurangabadkar, V. M., Balaraman, R., Austin, A., & Thirugnanasampathan, S. (2009). Analgesic and anti-inflammatory activity of a polyherbal formulation (PHFAROGH). Advances in Traditional Medicine, 9(3), 232-237.

Monks, F. J., & Knoers, A. M. P. (2005). Terapi Asam Urat. Jakarta: Elex Media Komputindo.

Nijveldt, R. J., Van Nood, E. L. S., Van Hoorn, D. E., Boelens, P. G., Van Norren, K., & Van Leeuwen, P. A. (2001). Flavonoids: a review of probable mechanisms of action and potential applications. The American journal of clinical nutrition, 74(4), 418-425.

Nuraini. (2011). Various benefits of fruit and vegetables. Yogyakarta: Andi.

Ode, S. (2012). Basic Concepts of Nursing. Yogyakarta: Nuha Medika

Okwari, O. O., Alagwu, E. A., Dasofunjo, K., Okwari, K. O., & Obi, L. (2015). Effect of aqueous leaf extract of Moringa oleifera on some renal function indices of rats. International Journal of Pharma Sciences and Research (IJPSR), 6(4), 777-782.

Oyewo, E. B., Adetutu, A., Ayoade, A., Adesokan, A., & MA, K. (2013). Repeated oral administration of aqueous leaf extract of Moringa oleifera modulated immunoactivities in wistar rats. J. Nat. Sci. Res, 3(6), 100-109.

Prameswari, O. M., & Widjanarko, S. B. (2014). Test Effect of Pandan Wangi Leaf Water Extract on Reduction of Blood Glucose Level and Histopathology of Diabetes Mellitus Rat Uji Efek Ekstrak Air Daun Pandan Wangi Terhadap Penurunan Kadar Glukosa Darah dan Histopatologi Tikus Diabetes Mellitus. Jurnal Pangan dan Agroindustri, 2(2), 16-27.

Putra, B., Azizah, R. N., & Clara, A. (2019). Potensi Ekstrak Etanol Daun Kelor (Moringa oleifera L.) dalam Menurunkan Kadar Asam Urat Tikus Putih. ad-Dawaa'Journal of Pharmaceutical Sciences, 2(2), 63–69.

Rahmawati, & Kusumastuti, A. (2015). The effect of steeping moringa leaves (moringa oleifera l.) in reducing uric acid levels in white rats (rattus norvegicus). College Journal of Nutrition, 4(4), 593-598.

Retnani, I., & Wahyuningtyas, N. (2012). Penghambatan ksantin oksidase oleh kombinasi ekstrak tempuyung (Sonchus Arvensis) dan salam (Syzygium Polyanthum) pada mencit hiperurisemia. Biomedika, 4(1), 17-22.

Rinayanti, A., Rahayu, S. T., & Syachfitri, R. D. (2016). Uji Aktivitas Penghambatan Xantin Oksidase Isolat 6, 4'-Dihidroksi-4-Metoksibenzofenon-2-O-Β-D-Glukopiranosida (C20H22O10) Dari Mahkota Dewa (Phaleria Macrocarpa (Scheff.) Boerl). Pharmaceutical Sciences and Research, 3(1), 1-11.

Riskesdas. (2018). Republic of Indonesia ministry of health research and development agency in 2018. Retrieved from: http://www.depkes.go.id/reso urces/download/infoterkini/materirakorpo p 2018/Hasil Riskesdas 2018.pdf

Rockwood, J. L., Anderson, B. G., & Casamatta, D. A. (2013). Potential uses of Moringa oleifera and an examination of antibiotic efficacy conferred by M. oleifera seed and leaf extracts using crude extraction techniques available to underserved indigenous populations. International Journal of Phytotherapy Research, 3(2), 61-71.

Sabilu, I. (2023). Correlation of age with cholesterol levels, random blood sugar (GDS) and uric acid. Window of Health: Journal of Health, 6(2), 131-141

Sashidhara, K. V., Rosaiah, J. N., Tyagi, E., Shukla, R., Raghubir, R., & Rajendran, S. M. (2009). Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents. European journal of medicinal chemistry, 44(1), 432-436.

Schlesinger, N. (2017). The safety of treatment options available for gout. Vol. 16, Expert Opinion on Drug Safety.

Singh, G., Lingala, B., & Mithal, A. (2019). Gout and Hyperuricaemia in the USA: Prevalence and Trends. UK: Rheumatol.

Suphachai, C. (2014). Antioxidant and anticancer activities of moringa oleifera leaves. Journal of Medicinal Plants Research, 8(7), 318-325.

Silbernagl, S., & Lang, F. (2000). Color Atlas of Pathophysiology. New York: Thieme Flexibook.

Singh, D., Arya, P. V., Aggarwal, V. P., & Gupta, R. S. (2014). Evaluation of antioxidant and hepatoprotective activities of moringa oleifera lam leaves in carbon tetrachloride-intoxicated rats. Antioxidants, 3(3), 569-591.

Tahta, A., & Upoyo, A. S. (2009). Analisis faktor-faktor yang mempengaruhi kadar asam urat pada pekerja kantor di Desa Karang Turi, Kecamatan Bumiayu, Kabupaten Brebes. Jurnal Keperawatan Soedirman, 4(1), 25-31.

Widiyanto, A., Pradana, K. A., Hidayatullah, F., Atmojo, J. T., Putra, N. S., & Fajriah, A. S. (2020). Effectiveness of warm Moringa leaf compresses for gout pain in the elderly in the villages of Kenteng, Nogosari, Boyolali. Avicenna: Journal of Health Research, 3(2), 103–113. https://doi.org/10.36419/avicenna.v3i2.422

Wijaya (2009). Study of technical standards of Indonesian national standards. SNI Biscuits 01-2973-1992 Argo Industrial Center, Ministry of Industry.

Witt, K. A. The nutrient content of moringa oleifera leaves.

Yang, R. Y., Lin, S., & Kuo, G. (2008). Content and distribution of flavonoids among 91 edible plant species. Asia Pacific Journal of Clinical Nutrition, 17, 275-279.

Zahroh, C., & Faiza, K. (2018). The effect of warm compresses on reducing pain in sufferers of gouty arthritis. Journal of Nursing and Midwifery, 5(3), 182–187. https://doi.org/10.26699 /jnk.v5i3.art.p182-187