Potential of Green Tea (Camelia Sinensis L.) in Improving the Function of the Liver in Mice Induced By Monosodium Glutamate (Msg)
Abstract
This study aims to examine the histological conditions of the liver given green tea in MSG-induced mice and to analyze the potential of green tea (Camelia Sinensis L.) in improving liver function in MSG-induced mice. The research was conducted for 30 days with test animals in the form of male mice strain Balb / c. This study used a factorial completely randomized design (CRD). Each treatment consisted of P0 as a control given distilled water 0.5 ml / w / day, P1 given 0.015 g / w / day green tea, P2 which was given MSG 0.84 g / w / day, P3 which was given MSG 0, 84 g / w / hr and 0.015 g / bb / hr green tea. The results showed that the MSG induction dose of 0.084 g / w / hr had an impact on reducing liver weight, increasing ALT levels and hepatocyte diameter. The administration of green tea with a dose of 0.015 g / bb / day in mice induced by MSG and without induction of MSG was able to increase liver weight, decrease ALT levels and hepatocyte diameter. The interaction of MSG and green tea occurs in the diameter of the hepatocytes, so it can be concluded that giving green tea a dose of 0.015 g / w / hr is able to repair damage to hepatocytes caused by MSG induction of 0.084 g / w / day.
References
Akbar, A. A. Daryoush, M. Ali, R., & Mehrdad, R. (2012). Green Tea Attenuates Hepatic Tissue Injury in STZ-Streptozotocin-Induced Diabetic Rats. Journal of Animal and Veterinary Advances, 11(12), 2081-2090.
Ali, H. T. (2007). Beneficial Effects of Nigella Sativa on the Testis tissues of Mice Exposed to UV Irradiation. Biology Department/Educational College/Mosul University.
Bhattacharya, T., Bhakta, A, & Ghosh, S. K. (2011). Long term effect of monosodium glutamate in liver of albino mice after neo-natal exposure. Nepal Med Coll J; 13(1): 11-16.
Chaturvedula, V. S. P., & Prakash, I. (2011). The aroma, taste, color and bioactive constituents of tea. Journal of Medicinal Plants Research, 5(11).
Devasagayam, P. A., Tilak, J. C. Boloor, K. K., Sane, K., Ghaskadbi, S. S., & Lele, R. D. (2004). Free Radicals and Antioxidants in Human Health: Current Status and Future Prospects. JAPI, 52.
Dimitrios, B. (2006). Sources of Natural Phenolic Antioxidants Aboratory of Food Chemistry and Technology. School of Chemistry, Aristotle University of Thessa-loniki.
El-Agouza, M. A., El-Nashar, E. D., & Eissa, S. S. (2010). The Possible Ultra Structural Ameliorative Effect of Taurine in Rat’s Liver Treated with Monosodium Glutamate (MSG). The Open Hepatology Journal, 2, 1-9.
El-Daly. A. (2011). The Protective Effect of Green Tea Extract Againts Enroflaxin Action on the Rat Liver: Histological, Histochemical, and Ultrastructural Studies. Journal American Science, 7(4), 669-679.
Eweka, O. A., & Iniabohs, F. A. E. (2008). Histological Studies of The Effect of Monosodium Glutamat on The Testis of Adult Wistar Rats. The Internet Journal of Urology, 1528-8390.
Godwin, A. Sina, I., Benjamin, A. (2010). Histological and biochemical markers of the liver of Wistar rats on subchronic oral administration of green tea. North American Journal of Medical Sciences, 2(8).
Heim, K. E., Tagliaferro, A. R., Bobliya, D. J. (2002). Flavonoids antioxidants: Chemistry, metabolism and structure activity relationships. The Journal of Nutritional Biochemistry; 13, 572-584.
Ibrahim, A. M., Buhari, O. G., Aliyu, B., Yunusu, I., Bisala, M. (2011). Amelioration of Monosodium Glutamate Induced Hepatotoxicity by Vitamin C. European Journal of Scientific Research, 60(1), 159-165.
Issabeagloo, E., Ahmadpoor, F., Kermanizadeh, P., Taghizadieh, M. (2012). Hepatoprotective Effect of Green Tea on Hepatic Injury Due to Leflunomide in Rat. Asian J. Exp. Biol. Sci., 3(1), 136-141
Madesh, M., & Hajnoczky, G. (2001). VDAC-Dependent Permeabilization of The Outer Mitochondrial Membrane by Superoxide Induces Rapid and Massive Cytochromec Release. J Cell Biol, 155, 1003-1015.
Marwa, A. A., & Manal, R. A. (2011). Evaluation of Monosodium Glutamate Induced Neurotoxicity and Nephrotoxicity in Adult Male Albino Rats. Journal of American Science, 7(8).
Noor, A. N., & Mourad, M. I. (2010). Evaluation of Antioxidant Effect of Nigella sativa oil on Monosodium Glutamate-Induced Oxidative Stress in Rat Brain. Journal of American Science, 6(12).
Onyema, O. O., Farombi, O. E., Emerole, O. G., Ugoha, I. A., & Onyeze, O. G. (2006). Effect vitamin E on Monosodium Glutamat Induced Hepatotoxicty and Stres Oxidative in Rats. Indian Journal of Biochemistry and Biophysics, 43, 20-24.
Pavlovic, V., Dusica, P., Gordana, K., Dusan, S., Tatjana, J. S., Snezana, C., Dragana, V. (2007). Effect of Monosodium Glutamate on Oxidative Stress and Apoptosis in Rat Thymus Mol. Cell Biochem, 303, 161–166.
Sandhar, K. H. Bimlesh, K., Prasher, S., Prashant, T., Salhan, M., & Sharma, P. (2011). A Review of Phytochemistry and Pharmacology of Flavonoids. International Pharmaceutica Sciencia, 1(1).
Singh, R., Akhtar, N., & Haqqi, M. T. (2010). Green Tea Polyphenol Epigallocatechin-3-Gallate: Inflammation and Arthritis. Life Sci., 86(25-26), 907–918.
Zeinab, M. A., El-Gohary, S. A., Khalifa, A. M., El-Said, F., & Yasmin, M. (2012). Comparative Studies on the Renal Structural Aspects of the Mammalian Species Inhabiting Different Habitats. Journal of American Science, 7(4).
Zowail, M. E. M., Khater, E. H. H., & El-Asrag, M. E. M. (2009). Protective Effect of Green Tea Extract against Cytotoxicity Induced by Enrofloxacin in rat Egypt. Acad. J. biolog. Sci., 1(1), 45-64.
Copyright (c) 2020 International Journal of Science and Society
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
.png)
.jpg)
.png)
.png)
.png)
.png)
1.png)
.jpg)
-modified.png)
-modified.png)
-modified.png)
